Director, Dmpk

At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We’re looking for people who are determined to make life better for people around the world.

At DICE Therapeutics, a wholly owned subsidiary of Eli Lilly & Company, we design and develop innovative therapies in immunology for patients with debilitating disease. Seeking to create a future where convenient oral medicines with biologic-like efficacy are available to patients with serious medical conditions, we are developing oral alternatives to medicines currently limited to injectable forms.

Responsibilities:

We are currently seeking a Director, Drug Metabolism and Pharmacokinetics, who will have scientific oversight of one or more of the small molecule discovery projects and will manage the in vitro and in vivo PK, ADME and bioanalytical assays. The candidate will be expected to collaborate with Medicinal Chemistry and Pharmacology to develop and implement studies vital to address key program DMPK issues and successfully advance research compounds into development.

Do you have experience as a DMPK Project Leader? Apply today to join the Lilly team!

• Provide scientific DMPK leadership and strategic direction to research project teams
• Offer scientific supervision for PK/ADME studies conducted at CROs
• Contribute to and influence the DMPK components in the screening funnel and criteria for compound selection and advancement in research programs
• Implement/manage quantitative bioanalysis of plasma and other biological matrices to support pharmacokinetic, toxicokinetics, and in vitro ADME analyses of novel small molecule therapeutics
• May supervise DMPK scientists
• Conduct PK and PK/PD modeling using non-compartmental and compartmental models
• Responsible for reviewing BA and TK reports from nGLP and GLP tox studies
• Organize and maintain research data
• Present data at project team meetings
• Guarantee the prompt completion and review of high-quality DMPK reports
• Contribute to nonclinical PK/ADME sections in regulatory documents (e.g., IB, IND, etc…)

Basic Requirements:

• PhD in a relevant scientific field
• 7-10+ years of work experience in Drug Discovery/Development DMPK

Additional Skills/Preferences:

• Strong publication record in the area of ADME/PK coupled with a high level of scientific curiosity and analytical thinking skills
• Prior success demonstrating strong leadership, collaboration and influence throughout the organization
• Prior management experience is a plus
• Experience in coordination of in vitro metabolism, DDI, transporters and/or protein binding studies
• Experience in performing or supervising the execution of bioanalytical assays and the development of such assays
• Familiar with ABI Analyst, Excel, WinNonlin Phoenix and Prism
• Capable of working autonomously and collaboratively in a multidisciplinary team setting
• Strong verbal, written communication and relationship skills including success managing external vendors
• Excellent interpersonal and organizational skills
• Meticulous and have an in-depth understanding of industry trends
• Success operating in a fast-paced, dynamic environment

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